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Int J Mol Sci ; 24(8)2023 Apr 21.
Article in English | MEDLINE | ID: covidwho-2290504

ABSTRACT

Neonatal venous thrombosis is a rare condition that can be iatrogenic or occur due to viral infections or genetic mutations. Thromboembolic complications are also commonly observed as a result of SARS-CoV-2 infections. They can affect pediatric patients, especially the ones suffering from multisystem inflammatory syndrome in children (MIS-C) or multisystem inflammatory syndrome in neonates (MIS-N). The question remains whether the maternal SARS-CoV-2 infection during pregnancy can lead to thromboembolic complications in fetuses and neonates. We report on a patient born with an embolism in the arterial duct, left pulmonary artery, and pulmonary trunk, who presented several characteristic features of MIS-N, suspecting that the cause might have been the maternal SARS-CoV2 infection in late pregnancy. Multiple genetic and laboratory tests were performed. The neonate presented only with a positive result of IgG antibodies against SARS-CoV-2. He was treated with low molecular weight heparin. Subsequent echocardiographic tests showed that the embolism dissolved. More research is necessary to evaluate the possible neonatal complications of maternal SARS-CoV-2 infection.


Subject(s)
COVID-19 , Ductus Arteriosus , Pregnancy Complications, Infectious , Venous Thrombosis , Male , Infant, Newborn , Female , Pregnancy , Humans , Child , RNA, Viral , COVID-19/complications , SARS-CoV-2 , Venous Thrombosis/drug therapy , Venous Thrombosis/etiology , Parturition , Vitamins
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